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Sputum characterization using SiGe high-frequency monolithic sensors


There is a growing demand for “all-electrical” sensor platform in conjunction with microfluidic techniques for biosensing in order to circumvent the existing problems of optical sensors, therefore, eventually leading to more compact lab-on-chip devices. SiGe high-frequency circuits offer the platform for all-electrical biosensing along with front-end electronics on the same chip. For tuberculosis detection, characterization of sputum using IHP SiGe BiCMOS high-frequency sensor is the main objective of the project.

IHP's Contribution

Designing of the monolithic BiCMOS sensor and the read-out circuit is the main contribution of IHP in the project. IHP along with University of Potsdam, has already established the first high-frequency dielectric immunosensor for creatinine. Polymer based microfluidic system was integrated with the BiCMOS high-frequency chips for particle concentration detection in aqueous solution.


This project receives funding by the Federal Ministry of Education and Research (BMBF) in the funding program "InnoProfile Transfer" with funding number 13N13862.



Project Partners

Leibniz-Institut für Photonische Technologien e. V.

Forschungszentrum Borstel

Ferdinand-Brau-Institut, Leibniz-Institut für Höchstfrequenztechnik im Forschungsverbund Berlin e.V.

Leibniz-Institut für Polymerforschung Dresden e.V.

Leibniz-Institut für Interaktive Materialien

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut e.V.

Leibniz-Institut für Analytische Wissenschaften

Leibniz-Institut für Wirtschaftsforschung Halle

Selected Publications

S. Guha et al., Analyst, 140, 3019-3027 (2015).

S. Guha et al., Analyst, 140, 3262-3272 (2015).

Ch. Wenger et al., Proc. Biodevices (2014).

S. Guha et al., IEEE, MTT- International Microwave Symposium (2014).

S. Guha et al., Journal of physics: conference series, 434, 012017 (2013).

S. Guha et al., European Microwave Conference, (2013).

The building and the infrastructure of the IHP were funded by the European Regional Development Fund of the European Union, funds of the Federal Government and also funds of the Federal State of Brandenburg.