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SUMCASTEC

Semiconductor - based Ultrawideband Micromanipulation of CAncer STEm Cells

Objective

SUMCASTEC aims at exploring a radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue.

IHP's Contribution

  • Development of BiCMOS technology supporting full integration of microfluidic channels for sensing application up to THZ frequencies
  • Design and development of mm-wave sensor circuits

Funding

Project is funded by FET Open programme under Horizon 2020 with 0.67 Mill € (IHP portion, for 42 months).

Project Partners

  • Université de Limoges
  • Bangor University
  • Padova University
  • National Italian Agency for New Technologies, Energy and Sustainable Economic Development
  • Creo Medical Ltd.

Selected Publications

M. Kaynak, M. Wietstruck, C. Baristiran Kaynak, St. Marschmeyer, P. Kulse, K. Schulz, H. Silz, A. Krüger, R. Barth, K. Schmalz, G. Gastrock, B. Tillack, "BiCMOS integrated Microfluidic Platform for Bio-MEMS Applications”, Proc. International Microwave Symposium (IMS), (2014).

 

C. Baristiran Kaynak, M. Kaynak, M. Wietstruck, St. Marschmeyer, P. Kulse, K. Schulz, H. Silz, A. Krüger, R. Barth, K. Schmalz, B. Tillack, "Modeling and Characterization of BiCMOS Embedded Microfluidic Platform for Biosensing Applications", Proc. Silicon Monolithic Integrated Circuits in RF Systems, (SIRF-BioWireless), 46, (2014).

The building and the infrastructure of the IHP were funded by the European Regional Development Fund of the European Union, funds of the Federal Government and also funds of the Federal State of Brandenburg.